Radioactive Estrogens in Tissues of Postmenopausal Women with Breast Neoplasms.
نویسندگان
چکیده
women with mammary carcinoma, the concentrations of total radioactive estrogen and the individual radiometabolites estradiol and estrone, and an uncharacterized fraction (Ep), were determined in several body tissues. Specimens of mammary tissue, mammary tumor, abdominal fat, muscle, and skin were removed 30 minutes after the infusion of the radioactive hormone. The median concentration of radioactive hormone in the tissues 30 minutes after the infusion of 680 Mg-of radioactive estradiol was 6.5 mjÃ-g/gmof tissue. Average concentrations of estradiol, estrone, and Ep frac tion were 76, 12, and 12 per cent, respectively. Although there was considerable variation in the amounts of radioactive estrogen in the tissues analyzed, generally greater amounts of radioactivity were found in the malignant tumor in comparison to mammary tissue and body fat tissues. The mean per cent estradiol in malignant tumor was greater than the amounts present in the other tissues. A method is described for the analysis of radioactive estrogens in tissue specimens.
منابع مشابه
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عنوان ژورنال:
- Cancer research
دوره 24 شماره
صفحات -
تاریخ انتشار 1964